BIO 1140 Lecture Notes - Intermediate Filament, Microfilament, Cytoskeleton

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9 Jun 2014
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Ex//keratin, neurofilament proteins (found in axons), nuclear proteins (involved in supporting the nucleus) The type of protein involved in making the intermediate filaments is based on origin. So you can use the type of proteins in the filament to find out origin (important for cancer to find origin of the cancerous cells to see how far the cancer has migrates) These types of proteins always have central alpha helix domain (has lots of alpha helix secondary structure) On the other side there are globular domains (folded, rounded areas) Presence of alpha helix area allow two intermediate filament to wrap around each other to produce a coiled-coil dimer and two of these wrapped together with another helix gives a protofilament-tetramer: dynamic character. Nuclear lamins-intermediate filament proteins that support the nucleus. Nuclear lamins have to be broken down and build back up again: functions. Tend to play roles that support the cell.

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