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Lecture 5

Lecture 5-6 Cell Membranes.doc

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University of Ottawa
Kathleen Gilmour

BIO 1140 Lecture 56 Cell MembranesReading Chapter 5Fluid Mosaic ModelSinger and Nicolson 1972Fluid lipid molecules in which proteins are embedded and freely floating The membrane is held together by noncovalent interactions FunctionsBecause the membrane is made up of lipids only molecules that are soluble in lipids can cross the barrier This is called selectively permeable Membranes provide a structure for organizing proteins Regulation of solute transport in and out of the cell and the organelles Eg the sodium pumpResponses to external signals is the first point of contact to the external environment Receptors and signal transduction occur on the membraneCelltocell communication recognition adhesion and exchange of materials are due to the membrane via gap junctions and plasmodesmata MembranesMitochondrial membranes have many proteins within them more than average has about 74 protein and 26 lipidPlasma membrane of Schwann cell myelin sheath has about 18 protein and 82 lipidLipidprotein assembly in which components are held together in a thin sheet by noncovalent bonds There are two fluid lipid layers with a mosaic of proteins within it It is approximately 10 nm thick The unit membraneGorter and Grendel 1925The lipid bilayer is the key component of the permeability of the barrier
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