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Lecture 11

Lecture 11 Signalling Pathways.doc

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Kathleen Gilmour

Topic 5 Celltocell Signalling Chapter 8Cells can respond to environmental chemicals and signalling molecules generated by other cells in the organism within multicellular organismsTypes of communication include gap junctions and plasmodesmata contact and chemical messengers In order for chemical messages to work there must be a signalling molecule first messenger that is synthesized by the cell and is used to generate the original signal and alter the activities of other cells These activities include changes in gene expression activities of the cytoskeleton cell death etc The response to the chemical messenger is through a signalling system First there is a receptor that binds the signalling molecule In the absence of the receptor the cell cannot respond to the signal Receptors can be in the membrane cytosolic or nuclear When the signalling molecule binds to the receptor it changes the activity of the receptor and thus turns of a signalling pathway that activates the cellular response Signal Transduction involves converting the first messenger primary signal to a cell response The primary messenger binds to the receptor which initiates a series of events known as the signal
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