BIO 2110 Lecture Notes - Lecture 18: Persistent Organic Pollutant, Combined Oral Contraceptive Pill, Androgen Receptor
6 Apr 2017
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Document Summary
Two phenyl rings that have different combinations of chlorine substitutions. Stable compounds, long half-lives, not degraded quickly by abiotic or abiotic factors. Banned in 70s, but still seen because they are so stable. Low levels are of concern for endocrine system and physiology. Some effects occur in environmental ranges, others do not. Crude high pcbs and pure low pcbs from fish oil consumed by rates. Blocks insulin signaling and causes diabetes like phenotype. Banned in lots of countries, but used in us and australia. Male testes show intersex characteristic, may show intersex characteristics. Others are alien invasives, emerging infectious diseases, over-exploitations. Many pharmaceuticals, lots of increases over the years. Selective serotonin reuptake inhibitors used to treat anxiety and depression. 3ppm per liter of water downstream in streams and lakes. Mechanisms linked to steroid synthesis pathways (not well understood) Fish head-kidney in several teleost fish like trout. Ssri fluoxetine has estrogen-like effects in male fish at low concentration.
