BIO 3119 Lecture Notes - Lecture 9: Overdominance, Coefficient Of Relationship, Genotype Frequency
16 Oct 2016
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Mating may be non-random because: relatives mate more often than expected by chance (inbreeding) Individuals may self more or less often than expected by chance. Individuals may mate with other individuals that are more or less similar o them in phenotype than expected by chance (assortative or disassortative) Calculating the inbreeding coefficient from pedigrees: f for individual i (fi) is the probability that the two alleles at a given autosomal locus are ibd. Alleles at a locus can be ibd only if they were inherited through (cid:271)oth of i(cid:859)s pare(cid:374)ts fro(cid:373) a (cid:272)o(cid:373)(cid:373)o(cid:374) ancestor (in this case individual a): parents not inbred but child is. Before beginning, if you are given a conventional pedigree, simplify it by removing all individuals that are u(cid:374)related to the (cid:272)o(cid:373)(cid:373)o(cid:374) a(cid:374)(cid:272)estor. This (cid:373)akes it easier to tra(cid:272)k the (cid:858)flow(cid:859) of alleles down the pedigree: you get . Chance of alpha 1 going down on both sides = inbred.
