BIO 3122 Lecture Notes - Lecture 15: Maximum Likelihood Estimation, Noncoding Dna, Molecular Evolution
23 Jan 2018
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L15 evol bio - the history of our genes. Alleles in popns coalesce to a common ancestor: change from g to t is change from black to red. If you work back, they will coalesce to a certain point of time in a single individual: two independent genealogies coalesced. Coalescence time varies for diff genes: coalescence time = how far back in time to go in this allele to find this joining (coalescence, diff genes have diff coalescence times. Shortest times are at the top leading to linger: mitdna has very short coalescence time -> inherited solely maternally, 152 000 - 300 000 mya. It is possible to trace gene genealogies and reconstruct the rise and spread of alleles. If not, what does this mean for estimating phylogeny and ages of divergence: explain your answers, write out your ideas and then discuss with a partner. Phylo relationships constructed by weighing evidence from multiple genes: estimated based on the entire genome.
