BIO 3147 Lecture 6: Lecture 6 - Explaining complexity again

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16 Oct 2017
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Sometimes the proteins are wrapped in vesicles for transport. Eg sonic, transforming growth factor beta, fiberglass, wnt. Also know what images are representing, eg what he taught us from each image. Higher cpg (hcp,usually down regulates genes that are on) and low cpg promoters(lcp genes of mature cells) A poised/paused stage and then an active stage. Need to be released from this for transcription to continue. Can explain why some genes can be turned on so quickly. Trans-activating can be activating or can be activating an inhibitor. Reporter gene - something that reports it"s presence, like fluorescent green protein. Enhancer determines where and when it is used, spatiotemporal regulation. Transcription factors determines whether enhancer is used or not. Allows scientist to figure out what the consensus sequence is. Dna needs consensus sequence to produce the protein. A bunch of transcription factors to allow one enhancer to work. Fundamental components: domains, protein-protein, trans activating domain, recruiting.

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