BIO 3147 Lecture Notes - Lecture 16: Growth Differentiation Factor, Myostatin, Telomere
Document Summary
Gdf 11 drops as you age (growth differentiation factor, a bmp factor, one of the transforming growth factor so it is a paracrine factor. He did more research, video stuck gdf in mice, reversed aging signs in hearts. Another theory from young niche cells around the young stem cells. Niche cells tell stem cells to stop dividing. Intrinsic changes in the niche cells not the stem cells. Probably multiple factors in the "silver bullet" solution to aging. One article talked about stem cells in the brain of mice. Need to immediately trigger an anti-inflammatory response so that the stem cells would not be imediately rejected by the mice. Destroyed early = died earlier, muscle and memory problems. Salmon with short telomeres have higher chance of surviving migration. But lots of factors, maybe telomeres have nothing to do with it. Took samples from 1800 salmon, only recaptured 21, <1% Using stem cells to treat brittle bone disease.
