BIO 3147 Lecture Notes - Lecture 20: Fgf8, Tbx4, Limb Development
Document Summary
3 of 6 is aging, limb and sex determination. Everything but about 50% is the stuff after. Neat link for the tetrapod limb development, see the factors. Gene to tell mesenchymal cells to secrete factors. Situate underneath surface ectoderm --> form a bulge. Will release factors to tell ectodermal cell to differentiate to forma limb. Starts with hox, then to the rest of the tfs. Can add an fgf to make limb chimera liked we talked about a lecture or two ago. Underneath it is the mesenchymal cells --> called the progress zone. Can stimulate other limb buds to form if you transplant it. Distal-proximal in limb, also helps with dorsal-ventral, anterior-posterior. If you remove the aer, signalling stops --> limb growth stops. Fgf 8 is the main thing, see bottom diagram. Audio recording started: 12:00 pm november 29, 2017. Age of progress zone determines what bones are formed. When progress zone buds out, it leaves behind those bones.
