BIO 3170 Lecture 17: TOPIC 17 DNA METHYLATION
6 Dec 2016
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Control of gene expression in eukaryotes: dna methylation. Control of gene expression in eukaryotes: regulatory proteins. Control of gene expression in eukaryotes: combinatorial control. Control of gene expression in eukaryotes: translation step. Cytosine: methylation - demethylation m5c occurs in: dna, rna (mrna, trna and rrna) Demethylation: ten-eleven translocation (tet) family enzymes oxidize: m5c. Adenine: methylation to demethylation m6a occurs in: dna and rna. Demethylation: feii- and -ketoglutarate-dependent fat mass and obesity- associated (fot) protein oxidize m6a to generate n6-hydroxymethyladenosine as an intermediate modification, and n6-formyladenosine as a further oxidized product. Prevalent m6a in messenger rna, formed through oxidative rna demethylation, may dynamically modulate rna protein interactions to affect gene expression regulation. More prevalent in rna = changes in me status of rna may dramatically modulate. Functional programs of cells are encoded in the genome. Genome stability: transmission through development and across generations. Want this to transmit genetic info across generations.
