BIO 3170 Lecture 18: TOPIC 18 TRANSITION STEP
6 Dec 2016
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Document Summary
Control of gene expression in eukaryotes: transition step. Control of gene expression at the level of mrna mrna transport and cellular distribution mrna stability. Controls the frequency of transcription initiation of a gene. Level: transcriptional, mrna maturation, mrna transport and localisation distribution to cellular compartments. Control at the level of mrna decoding: translation. Transcript half life: mrna stability, protein activity. Phosphorylation needs to take place. mrna transport from nucleus to cytosol mrna transport through the nuclear pore complex. When rna transcribed in nucleus rna produced must be made ready for export by binding various proteins selectively made by nucleopores made by glycoproteins for transport to cytosol. Pabps, poly a binding proteins (2-300 a) hnrnp = heterogenous nuclear ribonucleoproteins. Exon junction complexes ejc mrna transport from nucleus to cytosol. Sr proteins for serine arginine and are rna binding proteins. Once rna covered wit proteins recognized by pore through nucleofector and leave.
