BIO 3305 Lecture Notes - Lecture 1: Reversal Potential, Ion Channel, Facilitated Diffusion
14 Sep 2017
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Isolate cells form the environment: control of intracellular conditions, organize intracellular pathways into subcellular compartments. Slide #1: potential difference across the cmb. Inside the cell: -60mv; negative relative to outside cell: outside the cell: 0mv, can manipulate conc inside or outside of cell (test hypothesis) Find out which ions are present and then manipulate their conc. If equal voltage applied both ways, potential difference = 0. Mb proteins: can be more than half of the mb mass, two main types. Integral mb proteins: tightly bound to the mb, embedded in bilayer or spanning the entire mb, peripheral mb proteins, weaker association with the lipid bilayer. Mb transport: three main types, passive diffusion. Lipid soluble molecules: depends on conc grad, high -> low. Steeper grad results in higher rates: no specific transporters are needed, no additional energy is needed, facilitated diffusion, hydrophilic molecules, depends on conc grad, protein transporter is needed, no additional energy is needed, three main types of proteins:
