BPS 1101 Lecture Notes - Lecture 11: Fluoxetine, John Cade, Imipramine

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 1101
• Professor: William Ogilvie

Document Summary

Lunatic asylums became mental hospitals 1950s. Identified using animal studies: researchers identity patterns of behaviour the drugs produce, each generation had small improvements over previous, side effects, atypical antipsychotics 1972, clozapine, produces reduction in symptoms but via a different mechanism. Some kind of incident that occurs: typically, only become depressed for a small period of time. Anhedonia inability to experience pleasure: tricyclic antidepressants discovered by accident 1951. Imipramine: not effective for schizophrenia, elevated mood, physical transfer of neurotransmitters send nerve signal, nerve cells must reset after each transmission. Imipramine found to block serotonin reuptake: net effect is to amplify serotonin signals. Imipramine effects lots of things in the brain. Inhibits norepinephrine reuptake: dopamine antagonist, acetylcholine antagonist, histamine antagonist, side effects, accidental discovery of ipronazid, design new drugs to be more selective, tuberculosis drug, antidepressant effects. Inhibits monoamine oxidase (mao: mao helps regulate neurotransmitter amounts, body controls amount of chemicals by constantly making them and destroying them.