BPS 1101 Lecture Notes - Bismuth Subsalicylate, Gulf War Syndrome, Alka-Seltzer

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- Radithor = a patent drink that contained radioactive water, used to make you smarter
- Aspirin = acetasalicyclic acid (ASA)
- Bufferin = contains MgSO4, an antacid that helps to reduce stomach pains from aspirin
- Ibuprofen = found in Advil and Motrin
- Acetaminophen = found in Tylenol
- Anacin = contains ASA + caffeine
- APC tablet = contains ASA + phenacetin (older version of acetaminophen) + caffeine
- Tylenol migraine = contains acetaminophen + caffeine + ASA (ASA is not included in Canada)
- Tylenol PM = contains acetaminophen + diphenylhydramine (1st generation anti-histamine for drowsiness)
- Midol = acetaminophen + caffeine + pyrilamine (diuretic). For menstrual cramps
- Naproxen = found in Aleve
- Cafergot = an older form of isolated ergotamine still available today to relieve migraine
- Sumatotriptan = from the class of Triptans, which can stop migraines before they occur. Replaces serotonin
- Amphetamine/Benzedrine = decongestant
- Phenylpropanolamine (PPA) = decongestant that for a while was being used for appetite suppression now off the
market due to stroke
- Pseudoephedrine = found in Sudafed/Sinutab/Benylin, a decongestant that can be used to make methamphetamine
- Phenylephrine = a decongestant found in Sudafed PE (not as strong)
- Chlorpheniramine = 1st generation anti-histamine, makes you sleepy
- dextramethorphan = anti-tussive
- guanifesin = expectorant
- Mustine = inspired by mustard gas, a chemotherapeutic that causes DNA damage
- Cisplatin = chemotherapeutic which enters the cell and jams into DNA
- Taxol = chemotherapeutic derived from Yew
- Benzopyrenes/PAH = converted into a substance by the kidney that can react with DNA and cause cancer. Found
in anything that’s burnt (tobacco, steak)
- Stanozolol = steroid used by Ben Johnson in the Olympics, created by John Manson (all Canadian!)
- strychnine = acts as a stimulant in low doses, used in 1904 St Louis Marathon by Thomas Hicks
- Pervitin = methamphetamine tablets given to German soldiers
- Dianabol = steroid created by Dr Ziegler of the York Barbell Club, one of the first synthetic steroids used
- Diosgenin = derived from Mexican yams, used to make steroids
- tetrahydragestrinone = “The Clear”, undetectable steroid until 2002
- Salvarson 606 = 1st antibiotic developed by Ehlrich, from Trypan Red (trypanosomes)
- Prontosil = created by Domagk, antibiotic that is converted to sulfanilamide, which blocks folic acid production in
bacteria to produce coenzyme F
- cephalosporin = antibiotic discovered in Italian sewer. Blocks cell wall synthesis
- streptomycin = antibiotic that was discovered in chicken throats. Blocks protein synthesis in bacteria
- Tetracycline = antibiotic that also blocks protein synthesis in bacteria.
- Chantix = partial nicotine agonist (patch) from plant which contains cytisine (similar to morphine). Morphine is
used to make varencline
- Thiomersal = preservative with mercury for vaccines. Shown not to cause autism
- Squalene = lipid adjuvant which was thought to have caused Gulf War Syndrome, but this was not even in military
vaccines at the time.
- Alka Seltzer = sodium bicarbonate (antacid) + ASA + citric acid (makes fizz)
- Mg(OH)2 = antacid, in milk of magnesia. Problem is that it is a laxative
- Al(OH)3 = antacid, found in Gaviscon. Problem is that it causes constipation
- Maalox = magnesium hydroxide + aluminum hydroxide (therefore both effects cancel each other out). Also
contain simethicone (from silica gel) to prevent gas
- Pepto Bismol = poisons bacteria in the stomach
- Tagamet = stomach anti-histamine to reduce stomach acid, also causes gynecostomia (man boobs) as a side effect
- Omeprazole = in Prilosec, it is a proton pump inhibitor
- Esomeprazole = found in Nexium, also a proton pump inhibitor (the S-form of the previous chemical)
- diphenydramine = 1st generation anti-histamine found in Benadryl. Makes you drowsy
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