BPS 1101 Lecture Notes - Lecture 3: Kikunae Ikeda, Cytochrome P450, Paracetamol

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Cutting hole into skull to relieve pressure on the brain! Pain felt in thin tissue surrounding the brain! Blood vessels in head grow in diameter! Increased blood volume in head squishes tissue & generates pain! Increased blood volume may contribute to pain or help relieve depending on context! * difference depends on amount of enzyme produced! Aging adds to the pain ---> worse hangover! Alcohol increases liver function! don"t take acetaminophen for a hangover! Acetaminophen --------> glucoronyl transferase: (safe) removal from body! Kwok syndrome and msg (thought to be toxic)! When cooking in bulk, a lot of the avour is lost! Chemical reactions occur differently on a small scale and on a large scale! Consists of approximately 5% of our protein! When an absence of caffeine is felt, blood vessels dilate to compensate for the. Caffeine can help reduce the pain! expected usually caffeine-induced vasoconstriction! Causes st. anthony"s fire from extreme vasoconstriction!

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