BPS 1101 Lecture Notes - Lecture 12: Glucuronosyltransferase, Bhut Jolokia, Capsaicin
16 May 2016
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Acetaminophen -----> (glucuronyl transferase) --------> (alters foreign substances -----> Drugs pass through many barriers to reach target organ! Drug must make physical contact with biological molecules (protein)! Can be an antagonist or an agonist! A threshold amount must be there for them to stick to things ! 300mg administered ----> 30mg at target organ! 25mg is the threshold/ effective dose! removal from body)! Drug ----> desired response ----> re ex response! ex. vaccines may cause fever! Immune system works better in a fever situation! Can go into the brain and bind to other targets (causes sleepiness) ! Bell pepper rated 0 on the scoville scale! Blood acts as a coolant (like a radiator)! Always read the label for important safety information! Ex. in 1980s - 1990s drews test alternatives! Industry did not use it because it was not guaranteed whether courts would accept ! To make sure you don"t take the wrong drug! Most drug development money is spent here!
