BPS 2110 Lecture Notes - Lecture 6: Cyp2C19, Clopidogrel, 23Andme

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Cyp4502c19 3-4 % company with typing kit says closer to 15% Plavix is prodrug, converted to active compound by cyp2c19. *1 allele of the cyp2c19 gives normal function of plavix. *2 *3 have no effect in cells *17 has increased effect. Spartan rx device works by multiplying patient dna through pcr provides data. Pharmacogenetics: the assessment of the impact of a limited number of genetic factors affecting drug pharmacokinetics and or pharmacodynamics, e. g. cyp2c19 polymorphusm on plavix metabolism and its pharmaceutical activity. Pharmacogenomics the assessment of all genetic factors affecting drug pk and pd, must consider entire genome, genome wide association studies. 23andme kit determines 100 genetic traits for 199$ 10 related to drug response(likely cyp2c19) others related to inherited conditions, genetic risk factors, traits. (anne wojicki) creator wanted to bring power of genetic testing to everyday consumers, and to take advantage of the cumulated information for research purposes.

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