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Lecture 8

BPS 3102 Lecture Notes - Lecture 8: Methamphetamine, Weak Base, Active Transport

Biopharmaceutical sciences
Course Code
BPS 3102
Dr.Cory Harris

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Renal excretion
active transport can be in and out of tubules- both directions
PGP are eux pumps; always kicks outside of the cell, generally on the membrane
that is outside the body
ionization can impact passage across tubules
ocharged species stay in the aqueous urine
omethamphetamine is a weak base; in basic environments, is non ionized
oin acidic environments, it is protonated.
pulmonary elimination
not a large contributor
excretion of gaseous, unchanged drugs rather than metabolites
alcohol passively di#uses into the lungs and is breathed out (concentration
gradient favors moving out to the atmosphere)
Salivary eliminiation
pH of saliva varies from 5.8-8.4
lipid soluble, 1
E#ect on Elimination
First order elimination
volume of distribution: talking about the total drug
the larger the volume of distribution; generally sequestered in other depots
small VofD-usually limited to the bloodstream (heavily charged, large, hydrophilic),
generally eliminated faster
Zero order elimination
slower elimination at high drug concentrations
as the concentration increases, the amount eliminated stays the same per unit
steady state concentration: rate of absorption =rate of elimination
best achieved with IV infusion, steady release patches or delivery system
usually give a high loading dose, so that the concentration increases to the ideal
dose level, then keep giving the maintenance dose level
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