CHM 4139 Lecture Notes - Lecture 7: Elimination Reaction, Covalent Bond, Reagent
13 Oct 2016
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Chm 4139- lecture 7: mechanism of enzyme action (cont"d) **if the question asked what type of catalysis, we have to identify the type of catalysis and use evidence to prove: acid/base catalysis (cont"d) Enzymes will not donate its hydrogen and affect the ph. Enzymes catalyse reactions through general acid/base catalysis by: providing a lower energy barrier proton transfer that activates the substrate, reducing transition state energy by neutralizing unfavourable changes, metal ion catalysis (appendix a) Enzymes that bind transition metals (fe,cu,zn,mn) tightly are called metalloenzymes. Enzymes that bind alkali and alkali earth metal (k,na,mg ) calcium is no a co-factor, therefore it is not in this list. Involves the formation of a covalent bond between catalyst & the reactant during the reaction. It is a multi-step mechanism that decreases the g . Enzymes act as nucleophiles, while the substrate is the electrophile.
