CHM 4139 Lecture 10: CHM 4139- Lecture 10

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Chm 4139- lecture 10: enzyme inhibition (mid term 1 stops here) Lb allows us to extract km and vmax more easily than mm (without a computer). However, lb introduces more error than mm at low rates. Thus, a small error on v leads to a large error on 1/v. Nowadays, we mostly use lb for inhibition studies. It is the process of decreasing the rate of an enzyme reaction by the use of an inhibitor. Inhibitor: a molecule that binds to the enzyme and causes inhibition. Types of inhibition: reversible inhibitions: a temporary process that can be relieved, competitive: in this type of inhibition, the substrate and inhibitor exhibit structure similarity, making them compete for the same active site. Eg: e + s e s e + p. E + i e i + s no reaction. A competitive inhibitor acts by reducing the concentration of free enzyme available to bind to substrate, and therefore decrease [e s].

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