CHM 4139 Lecture Notes - Lecture 18: Ketone, Epimerase And Racemase, Hydrolysis
16 Nov 2016
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Document Summary
Enzymes are employed in biocatalysis for 2 general applications: direct synthesis of a desired compound. The exquisite selectivity (chemo-, region-, stereo-) of enzymes is exploited to synthesize only the desired compound. : direct asymmetric synthesis (synthesize one enantiomer only) of an enantiopure compound. The biocatalyst can be used in a single step of a multiple step synthesis where the other steps acre traditional organic synthesis reactions. E. g: separation of compounds from racemic mixtures prepared chemically. Deracemization: reactions in which 2 enantiomers are interconverted by stereoinversion process. Stereoinversion does not mean reracemization, cannot be used interchangeably. This transforms a racemix mixture into a non-racemix mixture into a non-racemix mixture without any change to the composition of the molecule. 1 (no removal/adding of any new atoms into the molecule. ) First step, only one of the enantiomer got oxidised. Second step require another dehydrogenase of another species that can oxidise the other enantiomer.
