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MT - Principles of Immunology Antibiotics

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Principles of Immunology11 What is ImmunityImmunity The protection against infectious disease conferred by immunization previous exposure bodys natural ability to resist infectionTwo Types of Immunity12 Innate NonSpecific Bodys natural resistance to disease Consists ofSkin Mechanical barrierslightly acidic due to sweat bactericidallowsuboptimal temperatureMucous Membranes Mechanical barrier Cilia in respiratory tracts lysosomes in secretions eg Tears Acidic pH urine stomach vaginaIron Binding Proteins proteins collect and recycle iron for use in blood limiting supply of iron for bacteriaPhagocytosis Cells swallow and lyse bacteria example macrophages PMNs monocytesComplement Series of steps that produce plasma proteins which kill invaders nonspecific13 AquiredAdaptiveSpecific ImmunityImmunity induced in the body as a result of encounters with invaders Has 2 main systems of protection Humeral and Cell Mediated CMI15 Humoral Immunity Consists of specific circulating antibodies also called immunoglobulins or Igsproduced by Blymphocytesplasma cells when exposed to a specific antigen non selfVariableregion recognizes antigen constant region chills111 There are 5 TYPES of Antibody G A M E DIgG Host defence can cross placenta to protect newbornIgA Host defence found in secretions DimerIgM Host Defence early immune response pentamerIgE Allergies May defend against parasitesIgD Unknown113 Responses of Humoral Immunity st1 Response Occurs when antigen is first introducedTriggers bestfit Bcell which will attach and multiply very quickly The Bcell is now an antibody which is detectable in blood in 510 days latent period Max at 21 days then dropsndndrd2 response Occurs when antigen is introduced a 2 or 3 time latent period shrinks max levels are higher and last longer and AB concentration stabilizes at a higher level Basis for BOOSTER SHOTSSerological Reaction Agglutination clumping caused by the attachment of antibodies to antigens Can be used to detect presence of antibodies in substance or can be used to detect unknown microorganisms with known antisera117 Cell Mediated Immunity
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