HSS 2305 Lecture Notes - Lecture 9: Y Chromosome, Histone Deacetylase, Vorinostat

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At the end of the lecture the student should be able to: Outline the levels of structure of chromatin and chromosomes. Describe the composition of nucleosomes; importance of histones to the structure of. Define epigenetics and describe how it relates to the nature vs. nurture debate. Detail the 3 primary mechanisms through which epigenetics can occur. Describe how the epigenome is established, highlighting examples from 2 critical developmental time points. Provide examples of environmental influences on the epigenome across an individuals lifetime. Describe the therapeutic implications of the epigenome in relation to cancer. Chromosome = organized structure of dna and associated proteins. Mechanism to package large amounts of dna into a small space. Each chromosome is a single, continuous piece of dna. Every human diploid cell contains 23 pairs of chromosomes (46 in total) Histone = specialized proteins that associates with and packages dna. Positive charge of histones interacts with negatively charged back bone of dna.

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