HSS 2305 Lecture Notes - Lecture 21: Atp Synthase, Chemiosmosis, Glycolysis

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5. 3 role of anaerobic and aerobic metabolism in exercise. 5. 4 oxidative phosphorylation in the formation of atp. 5. 11 diseases that result from abnormal mitochondrial or peroxisomal function. Glycolysis: oxidation of glucose to pyruvate: anaerobic phase of cellular respiration, occurs within cytoplasm; The first product is citric acid: occurs within the mitochondrion matrix, allows the production of 2 atp molecules at the substrate-level, allows the production 6 molecules of nadh + h+ (shuttle) leading to a production of 18. Atp: allows the production of 2 molecules of fadh2 (shuttle) leading to a production of 4. Muscle contraction expends much energy in sliding actin- and myosin-containing filaments, over one another. The energy that drives muscle contraction comes from atp (for the interaction troponin - ca+2). Muscle at work compared to muscle at rest: the rate of atp hydrolysis increases more than a 100-fold (for a skeletal muscle undergoing maximal contraction) compared to a muscle at rest.

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