HSS 2342 Lecture Notes - Lecture 9: Glycerol, Glycogen, Irreversible Process

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Breaking down nutrients for energy: di erent paths, lead to: Pyruvate: 3-c structure, used to make glucose. Acetyl coa: 2-c structure, those converted to acetyl coa cannot make glucose but are readily able to provide energy and be used to make fat, final energy pathways: Glucose to glucose-6-phosphate: image on next page, not reversible because third c is lost in co2 and there is no enzyme to retrieve it. Not getting energy fast enough from mitochondria, runs out of coenzymes run out (all have hydrogens), lactate produced which consumes and uses hydrogens -> lactic acid. This gure describes the fate of pyruvate under both aerobic and anaerobic conditions, although the majority of pyruvate is converted to lactate when oxygen is limited or the mitochondria are in limited supply. While this process occurs under resting conditions and in the presence of oxygen to some extent, it normally occurs during a high energy demand such as high- intensity exercise.

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