HSS 3305 Lecture Notes - Lecture 4: Coagulation, Innate Immune System, Vascular Permeability
23 Jan 2019
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Document Summary
Inflammatory reaction part of innate immune response to agents that cause cell injury. Nonsepcific response to any agent that causes cell injury: pathogen associated molecular patterns (pamp), damage associated molecule patterns (damp), Acute inflammation: occurs immediate after injury and lasts for 24-48hrs. Involves active phagocytic neutrophils, platelets that adhere to collagen at site of blood vessel injury and mediate the coagulation of blood to control hemorrhage related to tissue trauma. Involves mast cells found in tissue, often associated with blood vessels: presence of neutrophils and macrophages. Chronic inflammation: monocytes from blood and tissue that produce a variety of chemical mediators of inflammation, clean up debris produced by the acute inflammation and begin the healing process. Local inflammatory effects: capillary dilatation increased blood flow, increased warmth and redness, tenderness and pain caused by irritation of sensory nerve endings from swelling and pain. Mild inflammatory process self-limiting, subsides with tissue resolution.
