HSS 3305 Lecture Notes - Lecture 12: American Cancer Society, Tumor Suppressor Gene, Brca2

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 3305
• Professor: Benoit Leclerc

Document Summary

Heredity and tumors - predisposition results from multifactorial inheritance pattern. Brca2 mutation is comparable to that of hereditary retinoblastoma caused by dominant inherited traits mutant rb gene: other inheritance of certain genetic alterations multiple polyposis of colon, neurofibromatosis, multiple endocrine adenomatosis. American cancer society warning signals: change in bowel/bladder habits or function, a sore that does not heal, unusual bleeding or discharge, thickening or lump in breast or elsewhere, obvious change in wart or mole, nagging cough or hoarseness. The goal is to stop the development of late metastases, a current trend is to administer a course of anticancer drugs after surgical resection of some tumors. Immunotherapy: nonspecific immunotherapy is directed toward bolstering the patient"s own immune defenses so that the patient can deal more effectively with the tumor. Ifn regulates cell growth, inhibiting the growth of rapidly dividing cells.