HSS 3305 Lecture Notes - Lecture 18: Antithyroid Agent, Congenital Hypothyroidism, Thyrotropin Receptor

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 3305
• Professor: Benoit Leclerc

Document Summary

In adults myxedema low thyroid hormone and high levels of tsh: cause metabolic slowing; treatment administration of thyroid hormone. In infants congenital hypothyroidism (cretinism) failure of thyroid gland to grow or deficiency of enzymes to synthesize thyroid hormone: causes hypometabolism and slow normal cns growth, early diagnosis and treatment required for normal development. Disturbances of adrenal cortical function: abnormal adrenal cortical function produces abnormalities in the metabolism of carbohydrates and protein as a result of abnormal glucocorticoid secretion, disturbances of salt and water metabolism caused by disturbed mineralocorticoid secretion. Chromaffin cells secrete catecholamines in response to nerve impulses transmitted by the sympathetic nervous system: norepinephrine (noradrenaline), epinephrine (adrenaline, any emotional stress causes release of hormones. Pheochromocytoma: increased secretion of catecholamines: secretion pulses induce periodic episodes of high blood pressure and increase heart rate leading to pronounced cv effects and cerebral hemorrhage, continuous secretion induce hypertension, treatment: tumor resection.