MIC 4124 Lecture Notes - Lecture 2: Shigella, Transposable Element, Antibody
24 Jan 2017
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Document Summary
Getting stuff out: secretion systems, usually requiring energy. Getting stuff in: use of receptors, carrier molecules, energy dependent. Outer membrane protein that sense environmental stimuli. Alteration in outer membrane protein that phosphorylates a second protein. Downstream proteins are activated: n meningitidis example. Can cross epithelial membrane and travel to brain. Thermosensor regions in rna molecules that form hairpin in colder temperatures to inhibit translation. Increase in temperature (during fever) will release the hairpin and allow translation of virulence factors. Congregation of bacteria embedded in a host matrix. Dependent on cell density (must reach a certain density) Important in pathogenesis in lots of infections like cf. Acquiring new genes: horizontal gene transfer. Basic tenets of the framework: pathogenesis is result of interaction of host and microbe, outcome is determined by amount of damage to the host, host damage can result from microbial factors and or host response.
