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Lecture 3

MIC 4525 Lecture Notes - Lecture 3: Passive Immunity, Immune System, Antibody


Department
Microbiology and Immunology
Course Code
MIC 4525
Professor
William Yan
Lecture
3

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Microbiology 2016-01-19
Humoral – Antibodies get the foreign agent directly (B cells) (bacteria and fungal infections)
-Sometimes can no longer find the cell, that’s why you need t cells because they can find and kill
the foreign agent
Cell-Mediated Immunity (CMI) (parasites & viruses)
-Not antibodies that are important, it is the t cells that kill of the foreign bacteria.
-Don’t get foreign agents directly
-Intracellular bacteria
-Parasites need to be in a cell to be activated
(Non specific immune system) Skin, mucous ect…
(Specific) Antibodies & immune system
Disorders of immunity (Our immune system is not perfect)
1. Allergy- our immune system over reacts.
Theory in regards to nut allergies, (to many antigens) our bodies is being exposed to more
antigens it has not seen before
2. Auto immune diseases (immune system attacks itself)
3. Immunodeficiency states (having cancer, HIV)
4. Graft rejection (reducing the immune system so it does not reject the “subject”)
Immunization
Passive immunization
- Make antibodies (Purchasing antibodies) Is very expensive.
- Immune system will will still try to kill them
- Used rarely
Live-attenuated vaccines
- Contain live pathogens
- Your body will rank up antibodies for the long term, but there is a risk.
- Not recommended for people who have an immune problem
Killed Vaccines, sub-unit vaccines and toxoids
-Safer but less effected
- You will need a booster
Recombinant vaccines
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