NSG 3105 Lecture Notes - Lecture 9: Rheumatoid Nodule, Rheumatoid Arthritis, Hypermobility (Joints)

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Rheumatoid arthritis: chronic, systemic autoimmune disease characterized by inflammation of connective tissue in the synovial joints, typically with periods of remission and exacerbation. Ra occurs globally and affects all ethnic groups. Cause unknown: autoimmune theory suggests changes with ra begin when a susceptible host experiences an initial immune response to a varying antigen, triggers the formation of an abnormal immunoglobin. G: ra characterized by the presence of autoimmune antibodies against the abnormal igg, known as rheumatoid factor. Immune complexes are deposited in the synovial membranes causing an inflammatory response: manifestations: pain, stiffness, limited rom, inflammation. Most likely involved: joints of the hands, feet, wrists, elbows, shoulder, knees, hip, ankle and jaw. Morning stiffness (60min to several hours, gets better later in the day). Nonspecific manifestations such as fatigue, anorexia, weight loss, generalized stiffness may precede the onset of arthritic complaints.

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