PHA 3112 Lecture Notes - Lecture 2: Fetus, Lidocaine, Malignant Hyperthermia

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: Frank Feiner

Document Summary

Dyskinesia: tremor, muscle rigidity, slow movement, postural instability. Sx appear in middle age: sense of smell lost, excess salivation, hand clumsiness, poor handwriting, reduced voice volume. Involves structures in the extrapyramidal system: everything funnels through the globus pallidus which controls movement; it has two nts, via nt gamma amino butyric acid, striatum dopamine and acetylcholine. Normal movement: when da and ach are balanced. Slow loss of the dopaminergic neurons in the substantia nigra and therefore excess ach and gaba: defective brain proteins parkin/ubiquitin causing dopaminergic neurons to be destroyed. Lewy bodies in sn at autopsy = lewy body dementia (ultimately) Antipsychotic drugs block drug-induced parkinsonism (extrapyramidal syndrome) It is as if the re(cid:272)eptors are(cid:374)"t getti(cid:374)g e(cid:374)ough da. Treatment: the ideal does(cid:374)"t e(cid:454)ist (cid:894)to re(cid:448)erse or pre(cid:448)e(cid:374)t(cid:895, current drugs improve ability to perform activities of daily living, symptomatic relief, strategy boost dopamine drugs. **recall that nts do not stay too long in the synapse so you want to increase their effects.