PHA 3112 Lecture Notes - Lecture 1: Inverse Agonist, Neuropharmacology, Fluvoxamine
5 Apr 2017
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Document Summary
Pharmacology- a science that draws on info from multiple disciplines, anatomy, physiology, psych, chem, microbio. Pharmacology informs all aspects of clinical drug use. How drugs produce therapeutic and adverse effects. Reasons for giving a particular drug to a particular pt. Rational for selection of dosage, route and schedule of administration. No two patients respond identically to same drug regimen: ddi, physiologic variables, pathologic variable (diminished kidney/liver function), genetic factors. Right drug, patient, dose, route, time, documentation. Pharmacokinetics- what the body does to the drug. Absorption: see chart on slide 22, drug mvmt from site of administration into blood, may require crossage of membranes. Drugs bind reversibly with various blood proteins, most importantly plasma albumin. Drugs bound to albumin can"t reach their sites of action. Convert pharmacologically active compounds to inactive forms. Accelerate kidney excretion of highly lipid souble drugs, converting them into more polar compounds: special considerations. Nutritional status, drug metabolizing enzymes need cofactors from diet.
