PHA 3112 Lecture Notes - Lecture 11: Megakaryoblast, Reticulocyte, Platelet
12 Mar 2018
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Formed elements (blood cells) 45% of blood vol. , rbc, wbc, platelets (thrombocytes) Hematocrit = % of rbcs in blood volume. Erythrocytes (rbc: most abundant (4. 2-6. 2m) transport o2 + remove co2 from tissues, main functional constituent = hemoglobin. Leukocytes (wbc: protects the body by phagocytosis (forms immune antibodies too, act in tissues but also circulate in blood + lymphatic system. Thrombocytes (platelets: forms blood clots + controls bleeding, 1/3 of platelets are in reserve (spleen); releases cytoplasmic granules hemostatic process (150,00-400,000) Pluripotential stem cell: myeloid stem cell, myoblast, megakaryoblast, erythrobast reticulocytes erythrocytes, lymphoid stem cell. Cbc = # of rbc, wbc and platelets / unit. Wbc differential count = relative percentages of individual wbc type: basophils, neutrophils indicative of a pathology. Blood smear = morphological abnormalities (change in size, shape, colour) Erythrocytes indices: hematocrit (f: 37-47%; m:40-50%, reticulocytes (1-1. 5% of total rbc)
