PHA 3112 Lecture Notes - Lecture 4: Oncotic Pressure, Renal Blood Flow, Renal Artery
12 Mar 2018
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25% cardiac output: 1-2% to the medulla; 90% cortex. 99% (180l filtered/24hrs) absorbed; 1% (1-1. 8l of urine) excreted. Constricting/dilating: limiting the amount of flood that reaches the glomeruli. Mesangial cells similar to muscle cells; can contract/relax (will control the size of the capillaries) Pores in the glomeruli: blood is allowed to be filtered at a higher rate. Mesh: water, salt and glucose can get through; other bigger proteins cannot get through. Podocytes: highly differentiated epithelial cells; have a cell body; long finger-like projections (go around each capillary) form interdigitations (between them: final barrier for the filtration unit. Nephrotic syndrome: filtration system is so damaged, gene mutation encoded for a protein that was in between the foot processes. : rate at which plasma moves through glomerular capillaries (unites ml/min) Females: 85-125ml/min; males: 97-140ml/min for 2 kidneys: tissue size within the kidneys is greater in men. Children reach adult proportions by 2 yrs.
