PHA 4107 Lecture Notes - Lecture 13: Inflammatory Bowel Disease, Myofascial Pain Syndrome, Rheumatoid Arthritis
12 Jul 2018
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Document Summary
Induced by different stimuli, anywhere there are pain receptors can originate from those areas. In hollow organs, it is perceived as coming from somewhere else: usually well localized, but harder to pinpoint in hollow organs. Other pain disorders include cancer pain, migraine and other primary headaches and wide-spread pain of the fibromyalgia type: pain is nothing but a perception; different people perceive differently. When nociceptors are stimulated they transmit signals through sensory neurons in the spinal cord. These spinal neurons release the excitatory neurotransmitter glutamate at their synapses. Originate because of problems with cells (cancer cells, inflammatory cells, tissue injury, osteolysis) Starts in the periphery and ends up in the brain. Central transmission and perception of pain in the higher centre: Major ascending tracts that transmit pain from the periphery to higher centers are: 2- paleo-spinothalamic (medial spinothalamic) tract thalamus and other cortical areas as they ascend along the spinal cord:
