PHA 4107 Lecture Notes - Lecture 18: Glioblastoma Multiforme, Breast Cancer, Colorectal Cancer
12 Jul 2018
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Document Summary
Cancer: a proliferative disease: cancer is classified on the basis of the tissue from which it developed. Sarcomas: quite rare, osteosarcoma is the most common, sarcomas make up 1% of all tumors, they are cancerous of bone, connective tissue cells, muscle, you dont see them very often, not as treatable as other cancers. Leukemias and lymphomas: can occur in very young people. If children have cancers it most likely belongs to this group of cancers. Include brain cancer: glioblastoma multiforme is the most common, they arise in nervous system cells, tend to be untreatable, central and peripheral nervous system cells, 1% of cancers (2. 5% cancer-related deaths) If rb is active, it blocks entry into g1 if mutated cells can enter. Rb prevents entry into g1: s phase- tumor suppressors can also be responsible for monitoring genome and making sure there are no mutations. If unfixable p53 will go on to signal apoptosis and tell the cell to die.
