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Class Notes for Pharmacology at University of Ottawa

PHA 4107 Lecture Notes - Lecture 19: Monoamine Oxidase, Tricyclic Antidepressant, Tranylcypromine
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Psychoparmacology Drug What it does Monoamine hypothesis Antidepressants increase the levels of one or combination of three catecholamines (serotonin, norepinephrine, dopamine) by blocking their reuptake pumps or by inhibi...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 18: Glioblastoma Multiforme, Breast Cancer, Colorectal Cancer
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Cancer Basic Cancer: a proliferative disease Cancer is classified on the basis of the tissue from which it developed Carcinomas Classified based on the tissue that it develops in First group of cancers is the carcinomas an...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 17: Coniine, Tm1, Respiratory Arrest
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Pharmacodynamics and Toxicology Coniine Socrates died by drinking a cup of hemlock Hemlock contains coniine Symptoms: o Drowsiness, paresthesias, weakness, ataxia, nausea, profuse salivation and bradycardia > tachycardia >...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 16: Neutrophilia, Mineralocorticoid, Sex Steroid
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Antiinflammatory Drugs Corticosteroids as antiinflammatory agents The adrenal gland secrets numerous steroids of which aldosterone and hydrocortisone are the major ones. The steroids secreted are called adrenocorticoids. A...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 15: Prostaglandin D2, Prostaglandin E1, Prostacyclin
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Nonsteroidal Antiinflammatory Drugs PGs activate GPCRs distributed in many cellstissues to control inflammatory signals and physiological functions Prostaglandins in acutechronic inflammation: Hallmarks heat, redness, edem...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 13: Inflammatory Bowel Disease, Myofascial Pain Syndrome, Rheumatoid Arthritis
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Opioid Analgesics Classification of Pain Nociceptive: Represents the normal response to noxious insult or injury of tissues such as skin, muscles, visceral organs, joints, tendons, or bones. Examples include: o Somatic: mu...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 14: Vinca Alkaloid, Gemcitabine, Etoposide
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Chemotherapeutics Cancer therapies mostly target proliferative cells Not always proliferative cells In many tumors, there arent a lot of cells that are dividing For that reason some chemo are actually able to interfere wit...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 12: Diastolic Heart Failure, Cardiomyopathy, Afterload
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Cardiovascular Pharmacology The heart pumps blood into circulation >>blood pressure >> tissue perfusion Cardiac Output (CO): Heart pumping activity The amount of blood ejected per unit time (~6Lmin) CO= stroke volume x hea...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 11: Infection, Louis Pasteur, Bactericide
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Infectious Disease Antibiotics and Chemotherapy Chemotherapy: use of drugs to eradicate pathogenic organismsneoplastic cells in x of infectious disease or cancer Selective toxicity: drug inhibits vital function of invading...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 10: Locus Coeruleus, Anxiolytic, Clonazepam
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Anxiolytics Anxiety Etiology: o Risk factor for development of anxiety disorders: dispositional negativity as a core dimension of childhood temperament and adult personality an...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 9: Monoamine Oxidase, Tricyclic Antidepressant, Tyramine
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Psychopharmacology Antidepressants are among the most prescribed CNS Drugs Mood Disorders mania and depression have been described as poles apart in terms of affective disorders patients experiencing...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 8: Acetyl-Coa, Acetylcholine Receptor, Choline
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Cholinergic Pharmacology Synthesis of ACh Choline is transported into the presynaptic cholinergic nerve terminal by a high affinity Na choline cotransporter. The cytosolic enzyme choline acetyltansferase catalyzes the form...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 7: Detrusor Urinae Muscle, Adrenergic Receptor, Adrenergic
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Adrenergic Pharmacology How does the activation of sympathetic system relax the bladder while tightening the urinary sphincter (both are smooth muscles)? Due to the expression of different adrenergic receptor subtypes I ea...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 6: Autonomic Nervous System, Bronchus, Defecation
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Autonomic Nervous System Also called visceral, vegetative, involuntary Widely distributed throughout the body Regulates core functions which occur without voluntary control o Body temperature, secretions, circulation, brea...

Pharmacology
PHA 4107
Christine Pratt
PHA 4107 Lecture Notes - Lecture 5: N-Terminus, Ligand-Gated Ion Channel, Rhodopsin
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GPCRs and Ionotropic receptors Gprotein coupled Receptor Family (Metabotropic Receptors) Examples of GPCRs Acetylcholine (muscarinic) Adrenaline (adrenergic) 5hydroxytryptamine (serotonin) Opiates Dopamine Many peptides (p...

Pharmacology
PHA 4107
Christine Pratt

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