PSY 2116 Lecture Notes - Lecture 10: The Shortcut, Guanosine, University Of Manchester

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Four different types of polypeptides are used as subunits for the nicotinic receptor, and they are designated as: , , , and . A complete mature channel is made from two subunits, and one each of , and . There is one ach binding site on each of the subunits; the simultaneous binding of ach to both sites is required for the channel to open. The structure of glutamate receptors resembles that of potassium channels, and this has inspired the surprising hypothesis that glutamate receptors and potassium channels evolved from a common ancestral ion channel. Amino acid-gated channels mediate most of the fast synaptic transmission in the cns. 3 glutamate receptor subtypes: ampa, nmda, and kainate. Ampa-gated and nmda-gated channels mediate the bulk of fast excitatory synaptic transmission in the brain. Ampa-gated channels are permeable to both sodium and potassium but not calcium.

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