PSY 2301 Lecture 11: Drugs Part 2
22 Mar 2017
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Drugs and synapses: agonists and antagonists: nearly all drugs act at synapses and act at one (of seven) stages of transmission or another, synthesis, storage, release, receptor interaction, inactivation, Reuptake, degradation: for any drug, you need to know (tabs, transmitter it affects (directly, ago or ant to transmission, behavioural action or main use, state it affects and how (e. g. blocks increase) Agonists & antagonists ach example: so behavioural effects depends on ago/ant effects of drugs, ach agonists excite muscles, ach antagonists inhibit muscles, ago/and effects can happen at any of the 7 stages. Sensitization: opposite of tolerance increased responsiveness to the drug, not from constant use, but more likely form occasional use, ex. Amphetamine induced rearing (robinson & becker) rat study in motor behaviour: amphetamine is an agonist for da (stimulates da receptors) da involved, amphetamine administered occasionally, rearing behaviour measured.
