PSY 3132 Lecture Notes - Overdiagnosis, Mood Disorder, Collectivism

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Chapter 23: clinical utility of biological assessment measures of brain structure and function: The clinical utility of biological assessment measures was clearly illustrated in a study by hentschel et al, that was conducted with 100 patients referred to a university clinic because of memory difficulties (see figure 4. 4, page 119). In port-mortem studies , the brains of deceased patients are removed and the amount of specific neurotransmitters in particular brain areas can then be directly measured. Different brain areas can then be directly measured. Different brain areas can be infused with substances that bind to receptors and the amount of binding can then be quantified; more binding indicates more receptors. Another common method of neuro-chemical assessment involves analysing the metabolites of neurotransmitters that have been broken down by enzymes. A metabolite, typically an acid, is produced when a neurotransmitter is deactivated.

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