PSY 3301 Lecture Notes - Lecture 2: Microdialysis, Parallel Computing, Transcranial Magnetic Stimulation
13 Sep 2016
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Animal experiments: 1) negative (changes applied to the brain to see what happens): stimulation (ex: through chemicals), lesion, genetic models (mostly mice because they reproduce quickly) Helps to find treatments or ways to slow down the disease: 2) positive (looking at the brain while it"s behaving; you don"t influence the brain. Observational): behaviour-associated changes in anatomical details, brain chemistry, functional changes. Effects of lesions, stimulations on behaviours: in animal studies, use behaviours/stimulation the animal will understand. Post-mortem molecular analysis of changes produced by behaviour or experiences (tissue protein expression, tissue mrna expression, anatomical localization of cells, proteins: ex: teach an animal something, then observe physical or molecular aspects or changes of the learning. Analysis of cell fate in dividing cells either during development or in adult cell division using reporter genes. In vivo recording of molecules with in vivo microdialysis, in vivo enzymatic electrodes. Brainbows individual neurons in the brain can be distinguished from neighbouring neurons using fluorescent proteins.
