BIO200H5 Lecture Notes - Lecture 18: Suxamethonium Chloride, Artificial Ventilation, Pharmacodynamics
Document Summary
Designing for a specific person instead of giving a general drug for all. Variation is also between different species for the way they biotransform drugs. Whole point of variability is so they can survive cataclysmic event. No difference in blood levels, receptors respond differently. We know more of pharmacokinetic variability, and usually variability is pharmacokinetic, sick animals will have roughly same receptors as normal (so variability in pharmacodynamic is rare) Many disorders are polygenic, 3 or more genetic variations. 1% or more of population will have this abnormality. Plasma/serum cholinesterases - soluble in the blood, breaks down some drugs. Succinylcholine: muscle relaxer, use for surgery, you are paralyzed and will not be able to breathe. The effect will wear off; but some people will still experience effect so doctors have to put artificial respiration. Cocaine: half life - 1 hr, you don"t get high for so long,
