BIO200H5 Lecture Notes - Lecture 16: Circulatory System, Griseofulvin, Diazepam
Document Summary
Variability i :variations in drug response basic principles / Factors causing variability (overview: patient doesn"t take the drug. ( compliance )97 % get the prescription filled at a pharmacy. Patient perceives the disease to be serious: patient expectations create their own response. ( placebo effect ) Source of variability: definitions: (what is it?) The fraction of an administered dose that is absorbed and reaches the systemic circulation in its original (unmetabolized) form. Therapeutic equivalence (therapeutic effect a = therapeutic effect b) Different manufacturers - generic versus brand name: measurements: (how is bioavailability measured?, from therapeutic response indirect, difficult, from drug in urine indirect, limited to certain drugs, from blood samples direct, good. Measure: time to peak, height of peak, auc. Css (intravenous: important determinants of bioavailability, formulation different formulations of the same drug (especially crucial with p. o. administration) Filler (brand name versus generic: route different routes used for the same drug.
