BIO206H5 Lecture Notes - Lecture 14: Aminoacyl-Trna, Wobble Base Pair, Aminoacylation

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1 Oct 2016
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Functional sites: a, p, e, ef-tu, ef-g, mrna. 3rd position of codon has a degree of variability (wobble position); unusual nucleotide base called adenosine appears in the trna. Good fit between codon position number 1 and 2 but physically they are out in space, there is a degree of flexibility in the 3 prime codon position; wobble around in space trna charging: The second genetic code : important for correct translation to occur, for the amino acid to have the appropriate with the corresponding anticodon; has to be alanine or no fidelity in the code; specific set of enzymes. Attachment of the correct amino acid to trna. One aars per amino acid (20 in total) Once aa attached, the trna anticodon reads the mrna implication for specificity; evolved independently of one another so they all have a high degree of selectivity; anticodon and amino acid must appropriately match.

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