BIO206H5 Lecture 4: LEC 4 BIO206
Document Summary
1ary: linear sequence of a. as (numbered from n-terminus to c- terminus). We also name the individual amino acids in the 1ary sequence ex; ser-val-tyr-cys (svyc for short from) list of 20 a. as and their abbreviations in back of text. It"s the chemical properties of a. as that gives proteins it"s characters. It has important consequences: the single change in 1ary sequence can have enormous effect ex; hemoglobin in sickle cell anemia. @ position #6, a single a. a substitution from glutamic acid to valine results in a dysfunctional chain. It"s driven by a single point mutation which is adenine converted to uracil. Significant effects: may also have no perceivable effect at all. When the chain folds into regular patterns. Two most common are alpha helices and beta pleated sheet. We can predict whether a particular protein segment will form a helix or b sheet. H bonds run parallel to the long axis of the helix.
