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Class Notes for BIO304H5 at University of Toronto Mississauga (UTM)

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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 4: Electrochemical Gradient, Nernst Equation, Squid Giant Axon

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It"s the voltage difference in potential energy between 2 sides of membrane when cell is at rest. It"s a product of ion distribution + changes in membr
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 1: Medulla Oblongata, Neuroscience, Gap Junction

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Neurobiology studying physiology, anatomy, pathology of nervous system. Studying cells of ns and the organization of the cells in circuits that process
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 3: Cre Recombinase, Xfp Transceiver, Golgi'S Method

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Nervous system is made up of electrical excitability and chemical/electrical synapses\ But not all organisms have one but they do have genes for nervou
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 2: Golgi'S Method, Heinrich Wilhelm Gottfried Von Waldeyer-Hartz, Reticular Theory

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The neuron doctrine: is the concept that the nervous system is made up of individual cells, a discovery due to neuro-anatomical work of ram n y cajal a
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 1: Repolarization, Visual System, Exocytosis

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Not every animal has a brain, which is essentially just a conglomeration of neurons: ex; honey bees have ganglion" not exactly a brain though, ex; anim
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 2: Xfp Transceiver, Fluorescence, Polyadenylation

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Fluorescent proteins: rather than simply fluorescent dyes, we now use fluorescent proteins, such as gfp; it"s from a gene meaning you can express this
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 6: Nicotinic Acetylcholine Receptor, Alpha Helix, Disulfide

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Pumps + exchangers keep ion gradients stable gradients establish rmp and allow excitability. Ion channels create pore in the membrane allowing for chan
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 5: Apoptosis, Exocytosis, Antiporter

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Main purpose of neuron is to send nt. When signal invades nerve terminal we have openings where calcium comes in and binds to proteins that let vesicle
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 8: Voltage Clamp, Patch Clamp, Sodium Channel

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Recall: hodgkin + huxley tried to figure out the laws that govern movement of ions during the action potential. They looked at neuron during normal con
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 5: Ouabain, Atp Hydrolysis, Ion Transporter

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Sodium potassium pump (discovered by skou) we need replenishment of these ions because they leave via leak channels, transporters and ion channels. Ion
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture Notes - Lecture 1: Heart Rate, Exocytosis, Retina

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2 term tests - worth 25% each. The system of the body which works to conduct signals. System of nerve cells which is unique to animals. Not really beca
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UTMBIO304H5Adriano SenatoreWinter

BIO304H5 Lecture 3: BIO304 Lecture 3 Cont.

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In 1902, julius bernstein hypothesized that rmp depends only on k+ out vs k+in. So the k+ gradient sets the rmp meaning the na+ ions and other ions don
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