BIO304H5 Lecture Notes - Lecture 9: Retinal Ganglion Cell, Cav1.2, Exocytosis
Document Summary
The % available curve shows us how rmp influences the number of nav channels available for an ap - graph that shows how nav and kv in squid action function in action potential. Conductance curves of na and k tell us what percentage of channels will become activated. Depolarization from rmp will activate nav and kv channels according to the gna and gk conductance curves (a. k. a. percent activated) Ap frequency depends nav channel recovery from inactivation and the refractory period. H&h"s pivotal studies provided avenues for understanding other aspects of the action potential. Must be a time when we can"t get action potential because so many na channels have been inactivated so there is a refractory period. Hyperpolarization of vm often occurs after an ap. Lots of open kv channels drive vm closer to ek. The hyperpolarized vm removes inactivation of nav channels.
