#15 Excitation inhibition and integration

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16 Dec 2011
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Membrane potential depends on the most permeable ion. For it to be hyperpolarizing the most permeable ion has to be more negavtive than resting potential. Even if b is +ve (depolarizing) it can still be inhibitory and thus a+b is still smaller than a. No net ion flow through open channels, still ions flowing. Membrane potential at 0, there is no net synaptic currens (reversal potential) Both na+ and k+ can flow through it. At -90mv only na+ goes into the cell causing depolarization. No k+ movements because its at eqbm at -90. At -50mv, a lot of na+ goes into the cell (not as much as at -90 b/c of the reduced concentration gradient). And now a little k=+ goes out of the cell b/c its not at eqbm now. Smaller depolarization results b/c not as much na+ is going and a little k+ leaving (other words less +ve charge is entering the membrane)

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