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Lecture 20

BIO310H5 Lecture Notes - Lecture 20: Red Blood Cell, Anaerobic Glycolysis, Umbilical ArteryPremium

3 pages112 viewsFall 2018

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Nagham Abdalahad

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BIO310 Lecture 20
Organic modulators: 2,3-diphosphoglycerate
Mature red blood cells do not have mitochondria, and they respire via anaerobic
Large quantities of a metabolic intermediates 2,3-DPG, are formed in the red blood cell
during glycolysis, and the affinity of Haemoglobin for O2 decreases as 2,3-DPG levels
increase so the dissociation curve shifts to the right.
Conditions increase 2,3-DPG include hypoxia, decreased Haemoglobin, and lower pH
The normal P50 of human hemoglobin within red blood cells depends on a normal
intracellular concentration of 2,3-DPG
Presence of DPG (BPG) reduces Hb-O2 affinity
No mitochondria in red blood cells
Red blood cells will consume some kind of glycolysis for energy
Anaerobic glycolysis with many intermediates
One of intermediates is DPG is accumulated in blood cell
The more accumulation of DPG the more stress
The more DPG in tissue means less oxygen
And will allow for a relaxed state
Affected by metabolism and temp for relaxed state, so will require more oxygen
DPG also accumulated in the placenta
Circulation in placenta, every single oxygen molecule is used
Blood passes from heart to aorta to placenta, to give oxygen to all the cells and umbilical
We have hypoxic conditions
Every single tissue accumulates DPG
As the O2 partial pressure of blood falls, less and less of a drop in partial pressure is
required to cause unloading of 5 mL of O2 from each 100 mL of blood
Coordination with P50
High partial pressure of oxygen
Huge difference of oxygen
5mL per millimetre will require less difference of partial pressure between 30
and 40
The more we get less oxygenation the more ability of hemoglobin to give oxygen
for difference of partial pressure
pressure is one of the characteristics for sigmoid
compare green arrows, but same amount of oxygen delivered
more saturation the less the ability for delivery
that’s why oxygen more delivered from venus side to capillaries, and
most in the capillaries
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