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Lecture 20
BIO310H5 Lecture Notes - Lecture 20: Red Blood Cell, Anaerobic Glycolysis, Umbilical ArteryPremium
3 pages112 viewsFall 2018
Department
BiologyCourse Code
BIO310H5Professor
Nagham AbdalahadLecture
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BIO310 Lecture 20
Organic modulators: 2,3-diphosphoglycerate
● Mature red blood cells do not have mitochondria, and they respire via anaerobic
glycolysis.
● Large quantities of a metabolic intermediates 2,3-DPG, are formed in the red blood cell
during glycolysis, and the affinity of Haemoglobin for O2 decreases as 2,3-DPG levels
increase so the dissociation curve shifts to the right.
● Conditions increase 2,3-DPG include hypoxia, decreased Haemoglobin, and lower pH
● The normal P50 of human hemoglobin within red blood cells depends on a normal
intracellular concentration of 2,3-DPG
● Presence of DPG (BPG) reduces Hb-O2 affinity
●No mitochondria in red blood cells
●Red blood cells will consume some kind of glycolysis for energy
○Anaerobic glycolysis with many intermediates
○One of intermediates is DPG is accumulated in blood cell
○The more accumulation of DPG the more stress
○The more DPG in tissue means less oxygen
○And will allow for a relaxed state
○Affected by metabolism and temp for relaxed state, so will require more oxygen
●DPG also accumulated in the placenta
●Circulation in placenta, every single oxygen molecule is used
●Blood passes from heart to aorta to placenta, to give oxygen to all the cells and umbilical
artery
○We have hypoxic conditions
○Every single tissue accumulates DPG
● As the O2 partial pressure of blood falls, less and less of a drop in partial pressure is
required to cause unloading of 5 mL of O2 from each 100 mL of blood
○Coordination with P50
○High partial pressure of oxygen
○Huge difference of oxygen
○5mL per millimetre will require less difference of partial pressure between 30
and 40
○The more we get less oxygenation the more ability of hemoglobin to give oxygen
for difference of partial pressure
○pressure is one of the characteristics for sigmoid
○compare green arrows, but same amount of oxygen delivered
■more saturation the less the ability for delivery
■that’s why oxygen more delivered from venus side to capillaries, and
most in the capillaries
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