BIO310H5 Lecture Notes - Lecture 20: Red Blood Cell, Anaerobic Glycolysis, Umbilical Artery

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7 Dec 2018
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Mature red blood cells do not have mitochondria, and they respire via anaerobic glycolysis. Large quantities of a metabolic intermediates 2,3-dpg, are formed in the red blood cell during glycolysis, and the affinity of haemoglobin for o2 decreases as 2,3-dpg levels increase so the dissociation curve shifts to the right. Conditions increase 2,3-dpg include hypoxia, decreased haemoglobin, and lower ph. The normal p50 of human hemoglobin within red blood cells depends on a normal intracellular concentration of 2,3-dpg. Presence of dpg (bpg) reduces hb-o2 affinity. Red blood cells will consume some kind of glycolysis for energy. One of intermediates is dpg is accumulated in blood cell. The more accumulation of dpg the more stress. The more dpg in tissue means less oxygen. And will allow for a relaxed state. Affected by metabolism and temp for relaxed state, so will require more oxygen. Circulation in placenta, every single oxygen molecule is used.

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